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Among other criticisms, Stupak claimed that the FDA and Roche have been hiding information about the dangers of the drug (which both deny) Nevertheless, critics mostly folded up their protests after 2002 until the Vioxx recall in 2004 Practically speaking, since 217 other members of the House of Representatives, 51 senators, and the president are unlikely to agree with Congressman Stupak to eliminate user fees and raise the FDA s budget instead, consumer advocates concede that it is hard to see how else the agency could get enough money to be an effective regulator I don t know how much I would fault the agency for [not lobbying for a bigger budget], Dee Mahan said..

MoveAndSize.rc //Microsoft Developer Studio generated resource script. // #include resource.h #define APSTUDIO_READONLY_SYMBOLS //////////////////////////////////////////////////////////////////////// ///// // // Generated from the TEXTINCLUDE 2 resource. // #include afxres.h //////////////////////////////////////////////////////////////////////// ///// #undef APSTUDIO_READONLY_SYMBOLS //////////////////////////////////////////////////////////////////////// ///// // English (U.S.) resources #if !defined(AFX_RESOURCE_DLL) || defined(AFX_TARG_ENU) #ifdef _WIN32 LANGUAGE LANG_ENGLISH, SUBLANG_ENGLISH_US #pragma code_page(1252) #endif //_WIN32 //////////////////////////////////////////////////////////////////////// ///// // // Icon // // Icon with lowest ID value placed first to ensure application icon // remains consistent on all systems. IDI_MOVEANDSIZE ICON DISCARDABLE MoveAndSize.ICO #ifdef APSTUDIO_INVOKED //////////////////////////////////////////////////////////////////////// ///// // // TEXTINCLUDE // 1 TEXTINCLUDE DISCARDABLE BEGIN resource.h\0 END 2 TEXTINCLUDE DISCARDABLE BEGIN

opportunities. The contest between the music industry and upstarts like Napster have been extensively covered in the media, but the protection of music from piracy or other associated violations desired by copyright owners is a small portion of the space of problems that need resolution. The ability to securely deliver content and then continue to manage, monitor, and support its use at a remote location, with a minimal use of trusted third parties, can be critical to the success of many e-business models. Encryption is the most widely seen method of protecting content today but once the content is decrypted, it is open to abuse. Indeed, the problem of delivering content to untrustworthy recipients requires building the ability to reach out and retain control of content even after it is physically not in our possession. This persistent command of usage requires two basic components to be feasible.

purchased, the requirements for built-in quality are the same The difference is that the user may have more control over what happens during development if the system is contracted, as the quality requirements can be stated up front Suppliers catering to the pharmaceutical industry are very conscious of built-in quality, and they generally do this well The EU GMP Annex 11 [4] states: Validation should be considered as part of the complete life cycle of a computer system This cycle includes the stages of planning, speci cation, programming, testing, commissioning, documentation, operation, monitoring and changing And it continues with: The software is a critical component of a computerized system The user of such software should take all reasonable steps to ensure that it has been produced in accordance with a system of Quality Assurance The interpretation of this used to mean a supplier audit.

Gives you access to prewritten snippets of code for common scenarios. Displays a collapsible outline of the tags used on the current page, enabling you to quickly determine if tags are correctly nested, and to view and change tag attributes.

11

effects to Dorothy Hamill on ice skates, Digger the Dermatophyte, and a sexy blonde in a nightgown. But when it gave the go-ahead for Boots-type ads back in 1997, the FDA should have seen what was coming. No other commercials on TV are straightforward discussions of facts. Why would drug commercials be any different

3

Mg/Ca ratio for seawater is calculated (Hardie, 1996). During the resulting periods of low Mg/Ca ratio, associated with high sea level stands, nonskeletal carbonates are composed of (low magnesium) calcite, and marine evaporites are characterized by late forming KCl (sylvite), and an absence of Mg salts. By contrast, the periods of high Mg/Ca ratio are characterized by nonskeletal carbonate deposits composed of high magnesium calcite and aragonite (a polymorph of calcite), and marine evaporites in which MgSO4 formed during the nal stages of evaporation. The former periods have been termed periods of calcite seas, and are thought to be associated with high pCO2 and high surface temperatures; i.e. a Greenhouse Earth such as that which probably characterized the Cretaceous. The periods of high Mg/Ca ratio have been designated as periods of aragonite seas. These appear to correlate with times of low pCO2, and low surface temperatures, and include ice ages, i.e. an Icehouse Earth . Variations in pCO2 in the atmosphere in the geologic past are thought to have been largely due to the outgassing of CO2 from volcanic activity. Thus eustatic changes in sea level, changes in seawater chemistry, and variations in the concentration of CO2 in the Earth s atmosphere in the past might all be related to variations in the rates of sea oor spreading and plume activity.

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